Introduction Hemophilia A (HemA) and Hemophilia B (HemB) are X-linked bleeding disorders characterized by deficiencies in coagulation factors VIII (FVIII) and IX (FIX), respectively (1). Severe hemophilia (FVIII or FIX <0.01 IU/mL or <1% of normal) leads to frequent spontaneous or trauma-related bleeds, mainly in joints, muscles, and soft tissues (
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