Local anesthetics are essential agents in modern medicine and dentistry, widely employed to provide temporary loss of sensation during various diagnostic and therapeutic procedures. While they are generally considered safe when used appropriately, increasing utilization has led to a rise in reported cases of local anesthetic systemic toxicity. Thou

Despite strong evidence supporting non‑opioid modalities, real-world practice continues to show critical unmet needs in specific patient populations. For post‑operative pain among opioid‑sensitive individuals, a systematic review and network meta‑analysis of 23,902 patients demonstrated that IV lidocaine (OR 0.32), ketamine (OR 0.64), and gabapenti

Suzetrigine (Journavx) is an oral, selective Naᵥ1.8 sodium‑channel inhibitor approved by the FDA on January 30, 2025, for moderate-to-severe acute pain (1). It acts peripherally on Naᵥ1.8 channels in nociceptive neurons, avoiding central nervous system side effects associated with opioids (2). Two phase III randomized, double-blind trials in post‑b

Introduction Neuromuscular blocking agents (NMBAs) are widely used during general anesthesia and in intensive care settings to facilitate endotracheal intubation, optimize surgical conditions, and support mechanical ventilation. Despite their routine use, the safe management of NMBAs remains a significant challenge in clinical practice, especially

Introduction Regional anesthesia has emerged as a cornerstone in modern orthopedic surgery, offering targeted nerve blockade that enhances perioperative pain management and facilitates faster postoperative recovery. With the increasing global demand for orthopedic procedures projected to surpass 28 million annually the significance of regional anes

TIVA involves the administration of intravenous agents, typically propofol and remifentanil, without the use of inhaled gases. It offers benefits such as rapid recovery, minimal environmental contamination, and reduced postoperative nausea and vomiting (PONV). Inhalational anesthesia, utilizing agents like sevoflurane or desflurane, is favored for

The global rise in obesity presents unique challenges in medical practice, particularly in anesthesia and airway management. Obese patients, especially those undergoing bariatric procedures, often have complex airway anatomy, decreased pulmonary reserve, and coexisting conditions such as obstructive sleep apnea (OSA), increasing the risk of periope

In this insightful episode, we sit down with Dr. Rupan Bhadury, a leading Critical Care Specialist from Kolkata, West Bengal, India, to break down one of the most serious conditions managed in the ICU — Acute Respiratory Distress Syndrome (ARDS). With years of frontline experience, Dr. Bhadury shares a deep dive into the pathophysiology, clinical p

Various routine and emergency procedures, such as nasal examination, nasotracheal intubation, treatment of nasal and facial trauma, and increasingly prevalent office-based sinonasal interventions require nasal anesthesia. It is also required for treating facial and nasal abscesses. In certain situations, general anesthesia may not be feasible due t