Hello, and a warm welcome to MedX, where we bring you the latest news and insights from the world of medicine. FDA Approves First Gene Therapy for Wiskott-Aldrich Syndrome The FDA has approved the first cell-based gene therapy for Wiskott-Aldrich syndrome, marking a major milestone for patients with this rare and life-threatening genetic condition.

Introduction Pentacel, a combination vaccine developed against Diphtheria, Tetanus, acellular Pertussis Inactivated Poliovirus, Haemophilus influenzae type b (DTaP-IPV-Hib) to provide immunogenic protection (1). Regulatory standards mandate that combination platforms demonstrate immunologic equivalence or clinically relevant antibody responses when

Introduction Severe pertussis in early infancy continues to present high morbidity and mortality, largely driven by extreme leucocytosis leading to pulmonary hypertension and progressive cardiopulmonary failure (1). Despite vaccination efforts, resurgent cases underscore the need for timely recognition and aggressive management of critical disease

Introduction: Cutaneous lupus erythematosus (CLE) is a group of diseases within the spectrum of lupus that primarily manifests with skin lesions (1). Discoid lupus erythematosus (DLE), the most common form of cutaneous lupus erythematosus, presents with chronic, scaly, erythematous plaques that can lead to scarring. Conventional treatments, includi

Introduction: Systemic lupus erythematosus(SLE) is a chronic, multisystem autoimmune disorder that disproportionately affects women (~90% of patients) and presents significant management challenges due to its heterogeneity and resistance to conventional therapies (1). Despite new agents, sustained remission remains difficult for many patients. Upad

Introduction: Oral Allergy Syndrome (OAS), also known as pollen–food allergy syndrome (PFAS), is an IgE-mediated hypersensitivity reaction occurring primarily in individuals sensitized to pollens (1). Symptoms are triggered upon ingestion of raw fruits, vegetables, or nuts with homologous proteins to pollen allergens (1). OAS typically presents wit

Introduction: Oral Allergy Syndrome (OAS), also known as Pollen-Food Allergy Syndrome (PFAS), is an immunoglobulin E (IgE)-mediated allergic condition that manifests predominantly as rapid-onset oral symptoms triggered by consumption of certain raw fruits, nuts, and vegetables in individuals sensitized to specific pollens (1). Although typically ch

Introduction Elranatamab-BCMM is a humanized bispecific antibody that binds B-cell maturation antigen (BCMA) on malignant plasma cells and CD3 on T cells, redirecting cytotoxic activity against multiple myeloma cells (1). In phase 2 MagnetisMM-3, subcutaneous step-up dosing followed by weekly and then biweekly schedules achieved deep responses with

Introduction Elranatamab-BCMM is a bispecific antibody targeting B-cell maturation antigen (BCMA) on malignant plasma cells and CD3 on T cells, redirecting immune cytotoxicity to eliminate multiple myeloma cells (1). Its subcutaneous administration and step-up dosing schedule are designed to mitigate cytokine release syndrome (CRS) while allowing o