Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains a leading cause of morbidity and mortality worldwide. Understanding the immune landscape in sepsis is crucial for pathologists involved in diagnostics and research, as host immune signatures can inform prognosis, guide therapy, and elu

As we transition into 2026, Medsynapse recognizes that the most significant advancements in healthcare are born from collective expertise. Medical progress is not merely an individual pursuit; it is a testament to the shared intellect, unwavering resilience, and profound professional advocacy that defines our community. Behind every clinical breakt

Introduction Accurate histopathological grading is central to the diagnosis, prognostication, and management of prostate cancer. Since its introduction in 1966, the Gleason grading system has served as one of the most powerful predictors of clinical outcome. However, advances in diagnostic techniques, biopsy practices, and clinical understanding of

Introduction Frozen section examination plays a pivotal role in intraoperative decision-making, offering surgeons rapid diagnostic guidance when time-critical choices must be made. Whether assessing tumor margins, lymph node involvement, or confirming tissue identity, the reliability of frozen section reporting directly impacts surgical outcomes. D

Introduction Digital pathology has moved rapidly from a niche concept to a practical component of everyday diagnostics. By combining digital case management, whole-slide imaging (WSI), remote access, and algorithmic tools, laboratories are reshaping how specimens are reviewed and how diagnostic decisions are made. Read this interesting article to 1

Introduction Digital whole-slide images (WSIs) have opened new avenues for analyzing cellular organization and tissue architecture. Deep learning models such as HookNet-TLS automate the identification of tertiary lymphoid structures (TLS), which serve as important indicators of immune activity and response to therapies in various solid tumors. By d

Introduction Bone and bone marrow biopsies are central to diagnosing a wide range of conditions, including primary bone tumors, metastatic lesions, and hematologic malignancies. Because these specimens contain a mineralized matrix, decalcification is required to prepare them for routine histological processing. Decalcification enables thin-section

Introduction Molecular pathology has reshaped the understanding and management of lung cancer, especially non–small cell lung cancer (NSCLC). Advances in genomic profiling have revealed a spectrum of driver mutations that influence tumor behavior, treatment response, and prognosis. Identifying these biomarkers has become essential in tailoring targ

Introduction Sarcoidosis is a multisystem granulomatous disease characterized by non-caseating epithelioid granulomas across involved organs, including ocular tissues (1). Ocular manifestations may appear before systemic findings, creating diagnostic ambiguity when imaging and laboratory tests remain inconclusive (2). In these settings, conjunctiva