Eosinophilia-myalgia syndrome (EMS) is a multisystem disorder within the spectrum of eosinophil-associated problems. It was recognised in 1989 and till date 1,500 cases have been documented globally and nearly twice that number did not fulfil CDC's diagnostic criteria. Initially it was linked to the consumption of therapeutic L-tryptophan, but late

Familial Mediterranean Fever (FMF) is a genetic autoinflammatory disorder, which is characterized by recurrent episodes of fever and serosal inflammation affecting the abdomen, pleura, and joints, which manifest as intense pain. It is known by various names such as periodic peritonitis, familial paroxysmal polyserositis, periodic disease, Siegal-Ca

Introduction Lofgren syndrome is an acute form of sarcoidosis which is an idiopathic multisystem autoimmune disorder characterized by an exaggerated immune response leading to granuloma formation. While sarcoidosis primarily affects the lungs and thoracic lymph nodes, it can also involve the skin, eyes, liver, heart, and nervous system. The disease

Introduction Fibrodysplasia Ossificans Progressiva (FOP) is a rare, severely debilitating genetic disorder characterized by progressive heterotopic ossification (HO). This abnormal bone formation results in significant mobility restrictions and life-threatening complications such as thoracic insufficiency syndrome. The disease is caused by mutation

In this insightful interview, we sit down with Dr. Zubair Ashraf, a highly experienced Consultant Pulmonologist from Multan, Pakistan, to explore the pulmonary complications associated with rheumatological conditions. Respiratory involvement is a significant concern in autoimmune diseases, and Dr. Ashraf provides expert insights into diagnosis, man

Introduction Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disorder causing progressive heterotopic ossification (HO) of soft tissues. Management remains largely supportive, with pharmacological interventions targeting the aberrant bone morphogenetic protein (BMP) signaling pathway (1). This article outlines pharmacological and adju

Join us for an enlightening conversation with Dr. Francis Kynaston, a distinguished Consultant Rheumatologist from Dubai, as we explore the fascinating link between the microbiome and autoimmunity. Can we prevent rheumatic diseases before they even begin? This discussion delves into the latest research, potential preventive strategies, and the evol

Introduction Fibrodysplasia Ossificans Progressiva (FOP) is an ultra-rare genetic disorder characterized by progressive heterotopic ossification (HO) of connective tissues, leading to severe disability. The condition is caused by mutations in the ACVR1 gene, leading to dysregulated bone morphogenetic protein (BMP) signaling. The 2024 International

Are stem cell therapy and PRP (Platelet-Rich Plasma) truly revolutionary for ACL (Anterior Cruciate Ligament) regeneration, or is it just hype? In this exclusive interview, Dr. Manit Arora, a leading Shoulder & Knee Sports Surgeon at Fortis Hospital, Chandigarh, delves into the science, effectiveness, and future of these regenerative treatments in