Introduction: The immune system functions as a finely regulated network designed to defend against threats while preserving tissue integrity (1). When this balance is disrupted, immune dysregulation emerges as a foundational mechanism driving a wide range of chronic diseases (1). Rather than presenting as a single clinical entity, immune imbalance

Introduction The gut-lung axis challenges traditional organ-based thinking by highlighting continuous immune and inflammatory communication between the gastrointestinal and respiratory systems (1). Rather than functioning independently, these organs interact dynamically through circulating immune mediators, microbial metabolites, and epithelial bar

As we transition into 2026, Medsynapse recognizes that the most significant advancements in healthcare are born from collective expertise. Medical progress is not merely an individual pursuit; it is a testament to the shared intellect, unwavering resilience, and profound professional advocacy that defines our community. Behind every clinical breakt

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare, potentially life-threatening group of autoimmune diseases characterized by inflammation of small- to medium-sized blood vessels. The major subtypes include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with pol

Introduction Fatigue is one of the most pervasive and disabling symptoms experienced by individuals with chronic rheumatic diseases. Beyond joint pain, stiffness, and structural damage, persistent fatigue significantly affects daily functioning, emotional health, and overall quality of life. For many patients, fatigue is a primary reason for reduce

Introduction Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis mainly involving medium-sized arteries, leading to diverse clinical manifestations such as neurologic, renal, cutaneous, and gastrointestinal involvement (1). Despite the declining incidence due to hepatitis B vaccination, PAN carries a significant mortality risk in s

Introduction Polyarteritis nodosa (PAN) is a rare, systemic necrotizing vasculitis that primarily affects medium-sized arteries, sparing arterioles, capillaries, and venules (1). Unlike ANCA-associated vasculitides, PAN is typically anti-neutrophil cytoplasmic antibodies (ANCA)-negative and does not involve glomerulonephritis (1). Its clinical pres

Introduction: Polyarteritis nodosa (PAN) is a rare, systemic necrotizing vasculitis that predominantly affects medium-sized muscular arteries (1). It typically presents with constitutional symptoms, hypertension, and ischemic manifestations due to arterial inflammation and stenosis (1). A 60-year-old man with no vascular risk factors presented with

Join our upcoming webinar on Osteoporosis Risk Stratification and Treatment Strategies, led by Dr Asma Aljaberi, the President of Emirates Osteoporosis Society who is also a Consultant Endocrinologist, Co-Director of Bariatric-Metabolic Center, Department of Medicine, Tawam Hospital and Sheikh Tahnoon Bin Mohammed Medical City. Discover the integra