A 52-year-old man was newly diagnosed with Philadelphia chromosome–positive Chronic Myeloid Leukemia in chronic phase (CML-CP) during routine evaluation for fatigue and persistent leukocytosis. BCR::ABL1 testing confirmed active molecular disease, necessitating initiation of first-line tyrosine kinase inhibitor therapy, with emphasis on long-term e

Introduction Iron deficiency anemia (IDA) is one of the most common causes of anemia in clinical practice and is associated with fatigue, reduced functional capacity, and impaired quality of life (1). Oral iron therapy is usually considered first-line treatment; however, many patients fail to respond adequately due to poor tolerance, malabsorption,

Introduction Iron deficiency is highly prevalent in patients with heart failure (1). It is associated with reduced exercise tolerance, impaired quality of life, and increased risk of hospitalisation and mortality, regardless of the presence of anemia (1). Previous studies have shown that intravenous ferric carboxymaltose improves symptoms and funct

Introduction Gaucher disease (GD), a lysosomal storage disorder, results from the accumulation of glycosphingolipids due to deficient lysosomal glucocerebrosidase activity (1). GD arises from biallelic mutations in the glucosylceramidase β1 (GBA1) gene, resulting in defective acid β-glucosidase activity and the lysosomal accumulation of glucosylcer

Introduction: Gaucher disease (GD) is a lysosomal storage disorder caused by biallelic mutations in the GBA1 gene, resulting in deficiency of lysosomal acid β-glucosidase and accumulation of glucosylceramide (GlcCer) and glucosylsphingosine (GlcSph) within macrophages (1). Clinical manifestations in children may include hematologic abnormalities, h

Introduction Aplastic Anemia (AA) is a rare and life-threatening bone marrow failure disorder characterised by the lymphocyte-mediated destruction of early hematopoietic cells (1). Because of its high potential for morbidity and mortality, a systematic and rapid approach to its management is essential (1). A rapid and accurate diagnosis is critical

Introduction Educating a patient with aplastic anemia requires clinicians to move beyond technical explanation toward structured, empathetic, and safety-focused communication that supports long-term engagement in care (1) For many individuals, this diagnosis is overwhelming and unfamiliar, as most have never encountered the disease before their own

Introduction Aplastic anemia is a condition where the immune system attacks bone marrow, causing low blood cell counts and leading to fatigue, infections, and bleeding risks. For young patients with Human Leukocyte Antigen (HLA)-matched donors, allogeneic Hematopoietic Stem Cell Transplantation (HSCT) is preferred, while Immunosuppressive Therapy (

Overview The new 2024 BSH adult aplastic anemia guideline updates diagnosis by including molecular cytogenetics and high-sensitivity paroxysmal nocturnal hemoglobinuria (PNH) flow cytometry. It recommends Antithymocyte Globulin (ATG), cyclosporin, and eltrombopag as first-line treatment for severe cases. Hematopoietic stem cell transplantation (HSC